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PostSubject: placebo group   Wed May 02, 2007 8:20 pm

The lower cholesterol and risk of stroke in men : research, not involving the use of statins Study MRFIT an increased risk of haemorrhagic stroke among people with low levels of plasma cholesterol in the future not received confirmation of the Asian population of 7 cohort studies with a total of 1044 strokes. In addition, well-controlled study CARE risk of haemorrhagic stroke among Caucasians with IBS and low-cholesterol plasma has been minimal. The most important evidence in favor of the relationship between plasma levels of cholesterol and the risk of stroke is the ability of statins to reduce this risk. Statins new means of prevention or a new area of application? The statins in the prevention of complications serdechnososudistyh amply demonstrated. According to the 5 major prospective studies (4S, CARE, LIPID, WOSCOPS, TexCAPS / AFCAPS) serdechnososudistaya rate for long-term care statins reduced on average by 30%, mainly by reducing the risk of myocardial infarction and other consequences of IBS. However, in the treatment of statins has been identified and lower frequency of ateroskleroticheskogo destruction and other vascular basins sleepy main arteries and vessels of lower limbs. There was an exception and decrease the risk of cerebral stroke in people receiving statiny compared with the placebo group in these studies. But statistically reliable reduction in the incidence of brain stroke was observed only in studies on secondary prevention, that is, in patients with various forms of ischemic heart disease (stable stenocardia, postinfarktny cardiosclerosis, acute coronary syndrome). This study has highlighted 4S (simvastatin), CARE and LIPID (pravastatin), as well as the MIRACL (atorvastatin), which included patients (early 2496 h after the onset of acute coronary syndrome) and the duration of treatment (16 weeks) stood apart. In these studies, all patients was observed 20703 718 strokes (3,5%), a group receiving statiny were 310 strokes and 408 placebo group.

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