Tiazidnye diuretiki, especially in high doses, can violate carbohydrate exchange, as demonstrated by the increasing concentrations of glucose and whey glikolizirovannogo hemoglobin, as well as in violation of tolerance to oral and intravenous glucose load. The multicentric studies, for example, the study SARR (Captopril Prevention Project)  shows that the 6 years of observation, patients receiving tiazidnye diuretiki and b-blokatory, diabetes develops much more frequently than in patients receiving kaptopril. The medium and high doses tiazidnyh diuretikov increases content in the blood triglycerides, total cholesterol, high density lipoprotein cholesterol and low-density development that should also be taken into account when appointing them. Prominent among the metabolic effects tiazidnyh diuretikov took giperurikemiya, as a consequence of reduced urine excretion of uric acid. Given the metabolic effects, and long-term use tiazidnyh diuretikov must continuously monitor various parameters such as ECG, the level of lipids, glucose, potassium, and uric acid. Because of the large number of side effects, as well as the fact that at high doses, these drugs can affect sexual activity, and the athletes they can cause dehydration, tiazidnye diuretiki adolescent and young should be taken with great caution and in small doses . Recommended dosage gidrohlortiazida for adolescents and young people is 12,5-25 mg 1-2 times a day . The group tiazidnyh and tiazidopodobnyh diuretikov occupies a special place tiazidopodobny diuretik Indapamid Delayed release of the dose of 1.5 mg. This product has a dual effect on the one hand, it provides a slight increase natriyureza, like other drugs in this group, with the overall content of sodium in the vascular wall. But increasingly they are operating as intended vazodilatator is different in this respect from the rest tiazidnyh and tiazidopodobnyh diuretikov.